This program pursues major goals of the SLEuro mission, aiming to help young physicians develop their clinical and/or research skills,
expertise and network of scientific contacts in the SLE field.
For this purpose, SLEuro will award bursaries to applicants for an 8-week SLE-related training at a European Institution.
2019 TRAINING BURSARY PROGRAMME WINNERS:
Below is the list of SLEuro Centers that host the Training Bursary Programme
Click here to apply to the training bursary programme
Are you a SLEuro Center and would you like to host the programme in the future? Download the application
The Amsterdam Rheumatology and immunology Center (ARC) consists of the departments of rheumatology of both Amsterdam UMC (Amsterdam University Medical Center; locations De Boelelaan (former VU University Medical Center, VUmc) and Meibergdreef (former Academic Medical Center, AMC)) and Reade in Amsterdam, the Netherlands. The ARC / Amsterdam UMC has a dedicated SLE out-patient clinic, in which > 400 SLE patients are currently followed per year.Moreover, since 2001, basic, translational and clinical-epidemiological research on SLE is performed in our center using patient data and biosamples obtained from 260 SLE patients included in the SLE cohort Amsterdam with ongoing inclusion of patients. Both scientific research and wide clinical experience with the diagnosis and management of SLE have contributed to numerous publications of original articles and reviews in the area of SLE by members of our SLE center. The ISI Impact Factors of the publications related to SLE in the last 3 years of the leader of the SLE center (prof. Ronald van Vollenhoven) far exceeds 25. At your request, if necessary, I can provide an overview these publications.
Members of our SLE Center are currently:
Amsterdam UMC, PO Box 7057, 1007 MB Amsterdam, The Netherlands,
+31 20 – 444 50 8
Our Lupus Center is dedicated to clinical care of lupus patients and to translational and clinical research, with a strong cross-fertilization approach. Clinical care is provided by two full-time rheumatologists (Frédéric Houssiau and Farah Tamirou), a dedicated nurse coordinator (Séverine Nieuwland-Husson) and 4 rheumatology trainees. Every week, we run two Lupus Clinics, allowing us to see 40-50 lupus patients/week, half of them with lupus nephritis. We have access to our own in-patient beds for acute cases. Our Lupus Center is part of the European Reference Network ReCONNET (Connective tissue and Musculoskeletal Diseases). More than 600 lupus patients are registered in our electronic data base.
Lupus nephritis is our main clinical research topic, with more than 50 publications in this specific field dealing with the diagnosis, prognosis and treatment of renal involvement. Our group designed and run two European investigator-initiated trials which helped to define the optimal therapy of lupus nephritis. We recently defined the early proteinuria target which predicted long-term renal outcome.
Another strength of our center stems from our translational research unit, directed by Bernard Lauwerys. We have direct access to tissue, in particular kidney biopsies, from patients examined in the Lupus Clinic. Thus, we recently studied the renal transcriptome of lupus patients with active renal disease and were able to identify a subgroup of patients whose molecular signature predicted poor long-term outcome. We also study lymphocyte subtypes within the renal tissue. We have started an ambitious renal re-biopsy program,
within the frame of the Lupus Nephritis Trials Network.
Selected recent publications
10 Avenue Hippocrate 10, B 1200 Woluwe-Saint-Lambert, Bruxelles Belgium
Phone: 02 764 11 11
Fax: 02 764 37 03
The CHUC Lupus Clinic is located at the Rheumatology Department, Centro Hospitalar Universitário de Coimbra, in Coimbra, Portugal. It is an academic referral lupus center, founded in 2005, that specializes in the care of patients with Systemic lupus erythematosus (SLE) and related conditions.
The CHUC Lupus Clinic aims to provide excellent clinical care while seeking to improve knowledge on the disease and its treatment. We currently are the main providers of specialized clinical care to over 400 patients with SLE at our dedicated out-patient clinic. We are also strongly committed to postgraduate medical education in SLE, by providing a structured clinical educational program to visiting clinical fellows. We work in close clinical collaboration with clinicians with a special interest in SLE from other medical specialties and integrate a dedicated pregnancy clinic.
The CHUC Lupus Clinic is run by Prof. Luís Inês, MD, PhD, who is a senior attending rheumatologist and faculty member at the School of Health Sciences, University of Beira Interior. In addition to clinical care, we are actively involved in clinical research. Our main research areas are clinical outcomes research in SLE and developing new measures of SLE disease activity. The clinical research program is based in the CHUC Lupus Cohort, a prospective cohort of over 400 SLE patients and with more than 12 years of follow-up. We collaborate in national and international multicenter research in SLE and participate in SLE clinical trials. Prof. Luís Inês is a founding board member of the European Lupus Society (SLEuro) and the leading author of a chapter on SLE of the EULAR Textbook on Rheumatic Diseases, 2018 (3rd edition).
Selection of publications
Serviço de Reumatologia. Centro Hospitalar Universitário de Coimbra. Praceta Prof. Mota Pinto, 3000-075 Coimbra. Portugal
The Policlinic of Rheumatology & Hiller Research Unit, Heinrich-Heine-University Düsseldorf (UDUS) (Head: Prof. Dr. Matthias Schneider), is dedicated to routine patient care and basic and translational research on inflammatory rheumatic diseases. Approximately 2,500 in- and outpatients with various musculoskeletal and rheumatic diseases are seen per year; clinical focuses are early diagnosis strategies, systemic connective tissue diseases and a specialized outpatient clinic for pregnancy in rheumatic diseases; we contribute e.g. approximately 30% of the lupus patients documented in the National Database of the German Collaborative Arthritis Centres.
For local collaboration in care, education and research we host the administrative office of the Collaborative Arthritis Centre Rhine Ruhr (RZRR) at the Department of Rheumatology at HHUD. Nineteen rheumatologic departments in different hospitals and 80 resident rheumatologists are partners in the RZRR. Approximately 12 million people live in this area.
We were one of the six leading competence centres of the “Competence Network Rheumatic Diseases” funded by the German Federal Ministry of Education and Science. Due to our role the information technology expertise has a longstanding tradition. Several information technology projects have been conducted or established in our clinic (e.g. evaluation of the use of an APP for self-management in rheumatoid arthritis outpatients - MiDEAR; Patients’ attitudes towards electronic health record; an online registry for pregnant patients with inflammatory rheumatic diseases - RHEKISS).
In collaboration with the German Lupus Self-Help Organisation we run since 2001 a nationwide SLE cohort study (LuLa-study), which is completely performed based on patients reported outcomes focusing on burden of illness, therapy adherence, care, coping and similar topics. Exceptional competencies exist on the subject co-morbidities and their prevention on account of established non-interventional cohorts and cross sectional studies (arteriosclerosis study, Lupus erythematodes Langzeit-Studie (LuLa) study, Lupus-prevention pass, gender study. Further research focuses on the issue that conceptualised psychoeducational support may produce a significant and sustained improvement in coping skills of SLE patients and hence in their quality of life.
We successfully applied for multiple funding at EU, the Deutsche Forschungsgemeinschaft (DFG), the German Federal Ministry of Education and Research (BMBF), Ministry of Innovation, Science, Research and Technology of North-Rhine-Westphalia, patient organisations (e.g. Deutsche Rheuma-Liga and German LE Self-Help Community), and the pharmaceutical industry. In addition we are continuously sponsored by the Hiller foundation, which founded in 2015 together with the UDUS the Hiller Research Unit for Rheumatology coordinated by professorship for Experimental Rheumatology. In addition, our work is supported by our own unit of biometrics and a specific research unit for imaging in Rheumatology. A dedicated biobank compliant with the German and international data-protection regulations and research in biomarkers supports the (health services) research in view of the developments in the field of individualised medicine.
We are members of the European Reference Network on connective tissue and musculoskeletal diseases (ERN ReCONNET) established in March 2017.
Universitätsklinikum Düsseldorf, Moorenstr. 5, 40225 Düsseldorf
+49 (0) 2 11-81 00
Rue Gabrielle Perret-Gentil 4, 1211 Geneva, Bldg. C, Level 7
The Lupus Clinic at the Centre for Rheumatology, University College London has been running since 1979. Over that time we have treated over 600 patients with SLE and we are currently following over 400 patients.
We have extensive databases of clinical and serological information including activity measured by BILAG for each patient at each visit. Thus we have been able to write a large number of research papers looking at long-term clinical outcomes in SLE, for example cancer, damage, cardiovascular events, infection and neuropsychiatric lupus. We were one of the first centres to develop use of B cell depletion to treat patients with refractory SLE.
Our centre is affiliated to both the British Isles Lupus Assessment Group and the Systemic Lupus International Collaborative Clinics and we are therefore involved in multi-centre studies of lupus.
We also have a thriving programme of laboratory research in SLE and APS, including both mouse models and human studies. We have published work on T Cells, B cells, monocytes, autoantibodies and lipid profiles and the impact of these biological factors on clinical outcomes.
Many European fellows have spent time in our unit over the last 20 years, ranging from a few months to several years. Many of them published research based on projects that they did here.
Centre for Rheumatology, UCL Division of Medicine, Rayne Building, 4th Floor, 5 University Street, London WC1E 6JF
+44 (0)20 7679 2000
The area of expertise of Cochin’s Hospital Center includes systemic sclerosis (SSc), systemic lupus erythematosus (SLE) especially for its rare or complex presentations, antiphospholipid syndrome (APS), Sjogren's syndrome, mixed connective tissue disease (MCTD) and undifferentiated connective tissue disease (UCTD), myositis (dermatomyositis, polymyositis, antisynthetase syndrome) and relapsing polychondritis. In addition, we have a specific national expertise on pregnancies and connective tissue diseases (CTD).
The Department of Internal Medicine and the Department of Rheumatology A, both located in Cochin Hospital, University Paris Descartes, ensures a global management of these patients. Patients are referred based on the expertise of our centers and also driven by the respective networks of these 2 complementary medical specialties.
As a healthcare Provider, we provide:
Our center is part of a national network on rare diseases since 2004.
As a referral center for rare diseases, the rare systemic autoimmune disease reference center of Cochin is organised to fulfill 6 major missions:
Our center is implicated in the clinical and translational research in CTDs:
Both labs are strongly involved in translational research based on biomaterials collected in the respective cohorts of patients.
GFEV - Groupe Français d'Etude des Vascularites, Service de Médecine Interne, Hôpital Cochin, Bâtiment Saint Jacques, 27,
Rue du Faubourg Saint Jacques, 75679 Paris cedex 14
Clinical Immunology Unit (UIC) was formally created in 1996 in the Internal Medicine Department with internists directly involved in the field of Immunology. UIC has developed its activities in diagnosis and follow-up of patients with diseases resulting from altered immune mechanisms, mainly autoimmune diseases and immunodeficiencies.
In collaboration with the Immunology Service of our hospital and with the Immuno-Genetic department of ICBAS - Instituto Ciências Biomédicas Abel Salazar, Universidade do Porto, there are regular and proficuous contact with the laboratory techniques, their indications, methods, limitations and pitfalls. In addition to the theoretical approach in basic and laboratory immunology, residents will participate in the practical discussions associated with the use of the tests in real clinical cases.
Main areas of intervention:
Selection of publications
ISI factor for Lupus - Carlos Vasconcelos PhD from 2015-2018: 70.7861
1: van Vollenhoven R, Voskuyl A, Bertsias G, Aranow C, Aringer M, Arnaud L, Askanase A, Balážová P, Bonfa E, Bootsma H, Boumpas D, Bruce I, Cervera R, Clarke A, Coney C, Costedoat-Chalumeau N, Czirják L, Derksen R, Doria A, Dörner T, Fischer-Betz R, Fritsch-Stork R, Gordon C, Graninger W, Györi N, Houssiau F, Isenberg D, Jacobsen S, Jayne D, Kuhn A, Le Guern V, Lerstrøm K, Levy R, Machado-Ribeiro F, Mariette X, Missaykeh J, Morand E, Mosca M, Inanc M, Navarra S, Neumann I, Olesinska M, Petri M, Rahman A, Rekvig OP, Rovensky J, Shoenfeld Y, Smolen J, Tincani A, Urowitz M, van Leeuw B, Vasconcelos C, Voss A, Werth VP, Zakharova H, Zoma A, Schneider M, Ward M. A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS). Ann Rheum Dis. 2017 Mar;76(3):554-561. doi: 10.1136/annrheumdis-2016-209519. Epub 2016 Nov 24. Review. PubMed PMID: 27884822.
Impact Factor 2017/2018: 12.35
2: Tamirou F, D'Cruz D, Sangle S, Remy P, Vasconcelos C, Fiehn C, Ayala GuttierezMdel M, Gilboe IM, Tektonidou M, Blockmans D, Ravelingien I, le Guern V, Depresseux G, Guillevin L, Cervera R, Houssiau FA; MAINTAIN Nephritis Trial Group. Long-term follow-up of the MAINTAIN Nephritis Trial, comparing azathioprine and mycophenolate mofetil as maintenance therapy of lupus nephritis. Ann Rheum Dis. 2016 Mar;75(3):526-31. doi:10.1136/annrheumdis-2014-206897. Epub 2015 Mar 10. PubMed PMID: 25757867; PubMed Central PMCID: PMC4789692.
Impact Factor 2016: 12.811
3: Oparina NY, Delgado-Vega AM, Martinez-Bueno M, Magro-Checa C, Fernández C, Castro RO, Pons-Estel BA, D'Alfonso S, Sebastiani GD, Witte T, Lauwerys BR, Endreffy E, Kovács L, Escudero A, López-Pedrera C, Vasconcelos C, da Silva BM, Frostegård J, Truedsson L, Martin J, Raya E, Ortego-Centeno N, de Los Angeles Aguirre M, de Ramón Garrido E, Palma MJ, Alarcon-Riquelme ME, Kozyrev SV. PXK locus in systemic lupus erythematosus: fine mapping and functional analysis reveals novel susceptibility gene ABHD6. Ann Rheum Dis. 2015 Mar;74(3):e14. doi:10.1136/annrheumdis-2013-204909. Epub 2014 Feb 17. PubMed PMID: 24534757.
Impact Factor 2015: 12.384
4: Cervera R, Serrano R, Pons-Estel GJ, Ceberio-Hualde L, Shoenfeld Y, de Ramón E, Buonaiuto V, Jacobsen S, Zeher MM, Tarr T, Tincani A, Taglietti M, Theodossiades G, Nomikou E, Galeazzi M, Bellisai F, Meroni PL, Derksen RH, de Groot PG, Baleva M, Mosca M, Bombardieri S, Houssiau F, Gris JC, Quéré I, Hachulla E, Vasconcelos C, Fernández-Nebro A, Haro M, Amoura Z, Miyara M, Tektonidou M, Espinosa G, Bertolaccini ML, Khamashta MA; Euro-Phospholipid Project Group (European Forum on Antiphospholipid Antibodies). Morbidity and mortality in the antiphospholipid syndrome during a 10-year period: a multicenter prospective study of 1000 patients. Ann Rheum Dis. 2015 Jun;74(6):1011-8. doi:10.1136/annrheumdis-2013-204838. Epub 2014 Jan 24. PubMed PMID: 24464962.
Impact Factor 2015: 12.384
5: Marinho A, Carvalho C, Boleixa D, Bettencourt A, Leal B, Guimarães J, Neves E, Oliveira JC, Almeida I, Farinha F, Costa PP, Vasconcelos C, Silva BM. Vitamin D supplementation effects on FoxP3 expression in T cells and FoxP3(+)/IL-17A ratio and clinical course in systemic lupus erythematosus patients: a study in a Portuguese cohort. Immunol Res. 2017 Feb;65(1):197-206. doi:10.1007/s12026-016-8829-3. PubMed PMID: 27423437.
Impact Factor 2017/2018: 2.487
6: Marinho A, Taveira M, Vasconcelos C. Topics on vitamin D in systemic lupus erythematosus: analysis of evidence and critical literature review. Immunol Res. 2017 Apr;65(2):495-511. doi: 10.1007/s12026-017-8903-5. Review. PubMed PMID:28229285.
Impact Factor 2017/2018: 2.487
7: Bettencourt A, Carvalho C, Leal B, Brás S, Lopes D, Martins da Silva A, Santos E, Torres T, Almeida I, Farinha F, Barbosa P, Marinho A, Selores M, Correia J, Vasconcelos C, Costa PP, da Silva BM. The Protective Role of HLA-DRB1(∗)13 in Autoimmune Diseases. J Immunol Res. 2015;2015:948723. doi: 10.1155/2015/948723. Epub 2015 Oct 29. PubMed PMID: 26605347; PubMed Central PMCID: PMC4641944.
Impact Factor 2015: 3.53
8: Tamirou F, Lauwerys BR, Dall'Era M, Mackay M, Rovin B, Cervera R, Houssiau FA;MAINTAIN Nephritis Trial Investigators. A proteinuria cut-off level of 0.7 g/day after 12 months of treatment best predicts long-term renal outcome in lupus nephritis: data from the MAINTAIN Nephritis Trial. Lupus Sci Med. 2015 Nov 12;2(1):e000123. doi: 10.1136/lupus-2015-000123. eCollection 2015. PubMed PMID:26629352; PubMed Central PMCID: PMC4654096.
Impact Factor not available
Scopus CiteScore 2.88 (2017)
9: Langefeld CD, Ainsworth HC, Cunninghame Graham DS, Kelly JA, Comeau ME, Marion MC, Howard TD, Ramos PS, Croker JA, Morris DL, Sandling JK, Almlöf JC, Acevedo-Vásquez EM, Alarcón GS, Babini AM, Baca V, Bengtsson AA, Berbotto GA, Bijl M, Brown EE, Brunner HI, Cardiel MH, Catoggio L, Cervera R, Cucho-Venegas JM, Dahlqvist SR, D'Alfonso S, Da Silva BM, de la Rúa Figueroa I, Doria A, Edberg JC, Endreffy E, Esquivel-Valerio JA, Fortin PR, Freedman BI, Frostegård J, García MA, de la Torre IG, Gilkeson GS, Gladman DD, Gunnarsson I, Guthridge JM, Huggins JL, James JA, Kallenberg CGM, Kamen DL, Karp DR, Kaufman KM, Kottyan LC, Kovács L, Laustrup H, Lauwerys BR, Li QZ, Maradiaga-Ceceña MA, Martín J, McCune JM, McWilliams DR, Merrill JT, Miranda P, Moctezuma JF, Nath SK, Niewold TB, Orozco L, Ortego-Centeno N, Petri M, Pineau CA, Pons-Estel BA, Pope J, Raj P, Ramsey-Goldman R, Reveille JD, Russell LP, Sabio JM, Aguilar-Salinas CA, Scherbarth HR, Scorza R, Seldin MF, Sjöwall C, Svenungsson E, Thompson SD, Toloza SMA, Truedsson L, Tusié-Luna T, Vasconcelos C, Vilá LM, Wallace DJ, Weisman MH, Wither JE, Bhangale T, Oksenberg JR, Rioux JD, Gregersen PK, Syvänen AC, Rönnblom L, Criswell LA, Jacob CO, Sivils KL, Tsao BP, Schanberg LE, Behrens TW, Silverman ED, Alarcón-Riquelme ME, Kimberly RP, Harley JB, Wakeland EK, Graham RR, Gaffney PM, Vyse TJ. Transancestral mapping and genetic load in systemic lupus erythematosus. Nat Commun. 2017 Jul 17;8:16021. doi: 10.1038/ncomms16021. PubMed PMID: 28714469; PubMed Central PMCID: PMC5520018.
Impact Factor 2015: 12.353
Largo Professor Abel Salazar, Porto, 4099-001, Portugal
Presently the Karolinska university hospital is localized in two sites Karolinska Solna and Karolinska Huddinge. We have weekly lupus clinics at both sites where we perform inclusion visits to enter or follow up patients in our studies. Our center has performed studies with regard to SLE since 1995, when we started to collect the Karolinska lupus cohort. It has now been followed for > 20 years and contains information on more than 700 SLE patients (including deceased patients). The study design build on very detailed and structured inclusion of the patients approximately every 10 years. Large cross-sectional studies of all SLE patients at Rheumatology Karolinska were initially performed 1995-98, with an extended now completed follow-up 2004-14. Since 2015, a novel third follow up of prevalent and new cases is ongoing. Very detailed clinical characterization, life style questionnaires, fasting plasma, urine and DNA samples together with results from carotid ultrasound and bone mineral density measures have been collected. General disease activity, patient reported measures as well as lupus nephritis (affecting 40%) activity and detailed autoantibody profiles are recorded at inclusion. Data are stored in a common database. The total number of SLE patients recorded on our databases is today >700. Population based controls identified in the national population registry, individually matched for age, sex, and residency have been investigated in person according to the same structured protocol (n=320). Originating in the collected data we have conducted studies on selected topics. Previous studies have focused on cardiovascular disease, renal manifestations, biomarkers, microparticles, autoantibodies, fatigue, patient reposted outcomes and sub-phenotypes of lupus. In addition, ass. professor Iva Gunnarsson has collected a large database/biobank of renal biopsies (N=400) including paired biopsies performed before and after treatment (N=100). We have also performed structured longitudinal follow up studies including blood samples and PBMC from SLE patients on biological treatments such as rituximab and belimumab. Our collaborators in the lab are located at the Karolinska Solna site. Autoantibodies, B-cells and microparticles are the focus of several ongoing studies in the lab. Within the Swedish SLE network (>1500 patients) we have also performed, and been part of, larger genetic studies.
Some recent publications: (1-16)
Eugeniavägen 3, Solna, SE-171 76 Stockholm
The department of Rheumatology of Hôpitaux Universitaires de Strasbourg is located in the beautiful city of Strasbourg in the North-East of France. This center acts as the French National Reference Center for Rare Auto-immune diseases and is a major actor within the European Centers of Excellence for auto-immune diseases, being a member of two major European Networks of Reference (ERN) for rare diseases, namely the ERN ReCONNET and the ERN RITA. The center follows very large cohorts of patients with inflammatory rheumatic diseases, including Systemic Lupus Erythematosus and is interfaced with the INSERM (National Institute of Health) immune-molecular rheumatology unit UMR-S 1109. Participants to our training program will gain extensive clinical experience and practical knowledge of SLE and will be offered the possibility to perform research at the highest international level.
1 Av Moliere – 67098 Strasbourg
Our Lupus Center offers the unique opportunity to work closely with rheumatologists, dermatologists, nephrologists and internists, experts in systemic lupus. We have recently been labelled French National Reference Center for Rare Auto-immune diseases in close collaboration with Strasbourg. We are also part of the Euskampus consortium in collaboration with Bilbao (Spain, Prof Ruiz-Irastorza)
The center follows very large cohorts of patients with systemic lupus and is interfaced with an Immunology Lab, ImmunoConcept CNRS UMR 5164.
Our current research mainly focuses on:
- The role of different immunological actors (OX40L, soluble FasL and selectins) in lupus pathogenesis
- Immune mediators and metabolites involved in cardiovascular risk of SLE patients
Participants to our training program will gain extensive clinical experience and practical knowledge of SLE and will be offered the possibility to perform research at the highest international level.
Members of our SLE Center are currently:
Selected recent publications
Centre de référence des maladies auto-immunes systémiques rares, Hôpital Pellegrin, CHU de Bordeaux, 33076 Bordeaux