Literature Highlights – December 2019

Toward a novel prediction marker in SLE?

Comment on: Alexis Mathian, Suzanne Mouries-Martin, Karim Dorgham et al. Ultrasensitive serum interferon-α quantification during SLE remission identifies patients at risk for relapse. Ann Rheum Dis 2019;0:1–8. doi:10.1136/annrheumdis-2019-215571. Commented by: Carlo Chizzolini, University of Geneva | UNIGE, Division of Immunology and Allergology. The importance in SLE pathogenesis of type-I interferon (IFN-I) has been well documented … Read more

Being in the right place at the right time: when position matters

Comment on: Burke et al., “Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.” Sci. Transl. Med. 11, eaaw1736 (2019) Commented by: Andrea Doria, Mariele Gatto, Unit of Rheumatology, University of Padova, Italy. Email: adoria@unipd.it The advent of small molecules in the treatment of rheumatic diseases is part of a … Read more