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Large GWAS study in East Asian individuals with SLE

Comment on: Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus. Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu et al. Ann Rheum Dis 2020 Dec 3;annrheumdis-2020-219209. doi: 10.1136/annrheumdis-2020-219209. Online ahead of print. Commented by: Maria G. Tektonidou, First Department of Propaedeutic Internal Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of … Read more

Interferon lambda function in a TLR7-induced lupus model

Comment on: Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus. Rishi R Goel, Xinghao Wang, Liam J O’Neil et al. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5409-5419. doi: 10.1073/pnas.1916897117. Commented by: Maria G. Tektonidou, First Department of Propaedeutic Internal Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of … Read more

Lupus nephritis: New predictors of renal outcomes and treatment strategies.

Comment on: Moroni G, Gatto M, Tamborini F, et al. Lack of EULAR/ERA-EDTA response at 1 year predicts poor long-term renal outcome in patients with lupus nephritis. Ann Rheum Dis 2020; 79:1077-1083. Link: https://ard.bmj.com/content/79/8/1077 Commented by: Luís Sousa Inês, MD, PhD. CHUC Lupus Clinic, Rheumatology Department. Centro Hospitalar Universitário de Coimbra (CHUC). Coimbra, Portugal. Faculty … Read more

Lupus nephritis: New predictors of renal outcomes and treatment strategies.

Comment on Vanarsa K, Soomro S, Zhang T, et al. Quantitative planar array screen of 1000 proteins uncovers novel urinary protein biomarkers of lupus nephritis. Ann Rheum Dis 2020; 79:1349-1361. Link: https://ard.bmj.com/content/79/10/1349 Commented by: Luís Sousa Inês, MD, PhD. CHUC Lupus Clinic, Rheumatology Department. Centro Hospitalar Universitário de Coimbra (CHUC). Coimbra, Portugal. Faculty of Health … Read more

Lupus nephritis: New predictors of renal outcomes and treatment strategies.

Comment on: Furie R, Rovin BH, Houssiau F, et al. Two-Year, Randomized, Controlled Trial of Belimumab in Lupus Nephritis. N Engl J Med 2020; 383:1117-1128. Link: https://www.nejm.org/doi/full/10.1056/NEJMoa2001180 Commented by: Luís Sousa Inês, MD, PhD. CHUC Lupus Clinic, Rheumatology Department. Centro Hospitalar Universitário de Coimbra (CHUC). Coimbra, Portugal. Faculty of Health Sciences. University of Beira Interior. Covilhã, … Read more

Over a course of 46 years, clinical presentation of lupus nephritis (LN) has become less severe in the last years, leading to a better long-term renal survival: The indispensable role of renal biopsy and the need for a low-threshold to perform renal biopsy

Comment on: Changing patterns in clinical–histological presentation and renal outcome over the last five decades in a cohort of 499 patients with lupus nephritis.Moroni G, Vercelloni PG, Quaglini S, et al Ann Rheum Dis. 2018 Sep;77(9):1318-1325. doi: 10.1136/annrheumdis-2017-212732. Epub 2018 May 5. Commented by: Dimitrios T. Boumpas, Medical School, National and Kapodistrian University of Athens, Greece … Read more

Trial in Anifrolumab in Active Systemic Lupus Erythematosus

Comment on: ”Trial in Anifrolumab in Active Systemic Lupus Erythematosus” by E.F Morand, R. Furie, Y. Tanaka I.N:Bruce, A.D Askanase, C Riches, S-C Bae, P.Z Brohawn, L Pindea, A Berglind and R Tummala for the TULIP-2 Investigators. Published in NEJM 2020; 382:211-21 Commented by: Elisabet Svenungsson, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden Background: We … Read more

Withdrawal of low-dose prednisone in sle patients with a clinically quiescent disease for more than 1 year: a randomised controlled trial.

Comment on: “Withdrawal of low-dose prednisone in SLE patients with a clinically quiescent disease for more than 1 year: a randomised controlled trial” by Mathian A, Pha M, Haroche J, Cohen-Aubart F, Hie M, Pineton de Chambron M et al. Annals of the Rheumatic Diseases on-line first Dec 18 2019. Doi 10.1136/annrheumdis-2019-216303. Commented by: Anisur … Read more

Toward a novel prediction marker in SLE?

Comment on: Alexis Mathian, Suzanne Mouries-Martin, Karim Dorgham et al. Ultrasensitive serum interferon-α quantification during SLE remission identifies patients at risk for relapse. Ann Rheum Dis 2019;0:1–8. doi:10.1136/annrheumdis-2019-215571. Commented by: Carlo Chizzolini, University of Geneva | UNIGE, Division of Immunology and Allergology. The importance in SLE pathogenesis of type-I interferon (IFN-I) has been well documented … Read more