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Combined genetic deficiencies of the classical complement pathway are strongly associated with both systemic lupus erythematosus and primary Sjögren´s syndrome

Comment on: Lundtoft, et al., Arthritis Rheumatol, June 21 2022 (Accepted) DOI: 10.1002/art.42270 Comment by: Marta E. Alarcón-Riquelme Since long ago, we are aware that complement deficiencies are related with the appearance of SLE, particularly in the youth. However, we are not completely aware of the role of complement deficiencies in relation to the risk … Read more

SLEuro today commented articles

Title: Towards a standardization of the Physican Global Assessment (PGA) in Lupus? Comment on: Piga et al. Physician Global Assessment International Standardisation COnsensus in Systemic Lupus Erythematosus: the PISCOS study. The Lancet Rheumatology 2022 Volume 4, Issue 6, Pages e441-e449. https://doi.org/10.1016/S2665-9913(22)00107-2 Commented by: Professor Laurent ARNAUD, Department of Rheumatology, French National Reference Center RESO for … Read more

Quality indicators for systemic lupus erythematosus

Comment on: Quality indicators for systemic lupus erythematosus based on the 2019 EULAR recommendations: development and initial validation in a cohort of 220 patients. Commented by: Angela Tincani, Rheumatology and Clinical Immunology Unit, ASST-Spedali Civili and University of Brescia, Italy Systemic lupus erythematosus (SLE) is a very complex disease and in the last 20 years … Read more

Delineating the clinical value of MMF for joint manifestations

Comment on: Five-years drug survival of mycophenolate mofetil therapy in patients with systemic lupus erythematosus: comparison between renal and non-renal involvement. Joint Bone Spine 2021 Jun 22;105246. doi: 10.1016/j.jbspin.2021.105246. Online ahead of print Commented by: Thomas Dörner, Department of Medicine/Rheumatology and Clinical Immunology; Charite Universitätsmedizin Berlin, Germany While MMF has not been approved for SLE, … Read more

Effectiveness of mycophenolate/voclosporin combination therapy in lupus nephritis

Comment on: “Efficacy and safety of voclosporin versus placebo for lupus nephritis (AURORA 1): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial” (Lancet. 2021; doi: 10.1016/S0140-6736(21)00578-X.) Commented by: George Bertsias, Rheumatology Clinic, University of Crete School of Medicine, Greece Despite advances in the management of lupus nephritis, still a sizeable number of patients will fail … Read more

A gene-centric pathway stratification of SLE patients

Comment on: “Molecular pathways in patients with systemic lupus erythematosus revealed by gene-centred DNA sequencing” (Ann Rheum Dis. 2021; 80(1):109-117. doi: 10.1136/annrheumdis-2020-218636) Commented by: George Bertsias, Rheumatology Clinic, University of Crete School of Medicine, Greece SLE is characterized by remarkable clinical and immunological heterogeneity, which likely reflects the variety and complexity of the underlying molecular … Read more

Mapping Systemic Lupus Erythematosus Heterogeneity at the Single Cell Level

Comment on: “Mapping Systemic Lupus Erythematosus heterogeneity at the single-cell level” Nehar-Belaid, D., et al. Nat Immunol Sept 2020. https://doi.org/10.1038/s41590-020-0743-0 Commented by: Marta E. Alarcón Riquelme, Head of Medical Genomics Coordinator of 3TR, GENYO. Centre for Genomics and Oncological Research: Pfizer / University of Granada/ Andalusian Regional Government, Spain Technology has come to a point … Read more

Large GWAS study in East Asian individuals with SLE

Comment on: Meta-analysis of 208370 East Asians identifies 113 susceptibility loci for systemic lupus erythematosus. Xianyong Yin, Kwangwoo Kim, Hiroyuki Suetsugu et al. Ann Rheum Dis 2020 Dec 3;annrheumdis-2020-219209. doi: 10.1136/annrheumdis-2020-219209. Online ahead of print. Commented by: Maria G. Tektonidou, First Department of Propaedeutic Internal Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of … Read more

Interferon lambda function in a TLR7-induced lupus model

Comment on: Interferon lambda promotes immune dysregulation and tissue inflammation in TLR7-induced lupus. Rishi R Goel, Xinghao Wang, Liam J O’Neil et al. Proc Natl Acad Sci U S A. 2020 Mar 10;117(10):5409-5419. doi: 10.1073/pnas.1916897117. Commented by: Maria G. Tektonidou, First Department of Propaedeutic Internal Medicine, Laiko Hospital, Medical School, National and Kapodistrian University of … Read more

Lupus nephritis: New predictors of renal outcomes and treatment strategies.

Comment on: Moroni G, Gatto M, Tamborini F, et al. Lack of EULAR/ERA-EDTA response at 1 year predicts poor long-term renal outcome in patients with lupus nephritis. Ann Rheum Dis 2020; 79:1077-1083. Link: https://ard.bmj.com/content/79/8/1077 Commented by: Luís Sousa Inês, MD, PhD. CHUC Lupus Clinic, Rheumatology Department. Centro Hospitalar Universitário de Coimbra (CHUC). Coimbra, Portugal. Faculty … Read more