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Toward a novel prediction marker in SLE?

Comment on: Alexis Mathian, Suzanne Mouries-Martin, Karim Dorgham et al. Ultrasensitive serum interferon-α quantification during SLE remission identifies patients at risk for relapse. Ann Rheum Dis 2019;0:1–8. doi:10.1136/annrheumdis-2019-215571. Commented by: Carlo Chizzolini, University of Geneva | UNIGE, Division of Immunology and Allergology. The importance in SLE pathogenesis of type-I interferon (IFN-I) has been well documented … Read more

Being in the right place at the right time: when position matters

Comment on: Burke et al., “Autoimmune pathways in mice and humans are blocked by pharmacological stabilization of the TYK2 pseudokinase domain.” Sci. Transl. Med. 11, eaaw1736 (2019) Commented by: Andrea Doria, Mariele Gatto, Unit of Rheumatology, University of Padova, Italy. Email: adoria@unipd.it The advent of small molecules in the treatment of rheumatic diseases is part of a … Read more

2019 EULAR/ACR SLE classification criteria in practice

Comment on: Aringer M., Costenbader K., Daikh D., et al. “2019 European League against Rheumatism/American College of rheumatology classification criteria for systemic lupus erythematosus” Ann Rheum Dis 2019;78:1151–9. Papers 1-11. Commented by: Matthias Schneider, Heinrich-Heine- Universität Düsseldorf, HHU, Policlinic and Hiller Research Unit Rheumatology. E-mail: Matthias.Schneider@med.uni-duesseldorf.de The new EULAR/ACR are published and will change the perspective … Read more

EULAR recommendations for the management of antiphospholipid syndrome in adults

Comment on: EULAR recommendations for the management of antiphospholipid syndrome in adults. Tektonidou MG, et al. Ann Rheum Dis. 2019;78:1296-1304. Commented by: Maria G. Tektonidou, MD, PhD, Associate Professor of Rheumatology. Head of Rheumatology Unit, First Department of Propaedeutic Internal Medicine, School of Medicine, University of Athens, Greece Due to the rarity of Antiphospholipid syndrome … Read more

Tubular cell and keratinocyte single-cell transcriptomics in lupus nephritis

Comment on: Tubular cell and keratinocyte single-cell transcriptomics applied to lupus nephritis reveal type I IFN and fibrosis relevant pathways. Dar E, et al. Nat Immunol. 2019;20:915-927. Commented by: Maria G. Tektonidou, MD, PhD, Associate Professor of Rheumatology. Head of Rheumatology Unit, First Department of Propaedeutic Internal Medicine, School of Medicine, University of Athens, Greece … Read more

Low disease activity versus remission in SLE: is it ok to be “mediocre”?

Comment on: Petri M, Madger LS. Comparison of Remission and Lupus Low Disease Activity State in Damage Prevention in a United States Systemic Lupus Erythematosus Cohort. Arthritis Rheum 2018; 1790– 1795 Commented by: Laurent Arnaud, Department of Rheumatology, National Reference Centre for Rare Systemic and Autoimmune Diseases East South-West (RESO), Strasbourg, France. Twitter: @Lupusreference. Email: Laurent.arnaud@chru-strasbourg.fr … Read more

2019 update of the EULAR recommendations for the management of systemic lupus erythematosus

Comment on: Fanouriakis A, et al. 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus. Ann Rheum Dis 2019;78:736-45. Commented by: Nathalie Costedoat-Chalumeau, Internal Medicine Department, Cochin Hospital, Referral center for rare autoimmune and systemic diseases, Paris, France. The 2008 EULAR recommendations for the management of systemic lupus erythematosus (SLE) have … Read more

Lupus quality of care: Unmet needs for bridging the gaps across multiple healthcare settings

Comment on: Aggarwal I, Li J, Trupin L, Gaynon L, Katz PP, Lanata C, Criswell L, Murphy LB, Dall’Era M, Yazdany J. Quality of Care for the Screening, Diagnosis, and Management of Lupus Nephritis Across Multiple Healthcare Settings. Arthritis Care Res (Hoboken) 2019 May 6. doi: 10.1002/acr.23915. [Epub ahead of print] Link: https://onlinelibrary.wiley.com/doi/abs/10.1002/acr.23915 Commented by: … Read more

Improving mortality of SLE patients: How far did we progress?

Comment on: Tselios K, Gladman DD, Sheane BJ, Su J, Urowitz M. All-cause, cause-specific and age-specific standardised mortality ratios of patients with systemic lupus erythematosus in Ontario, Canada over 43 years (1971-2013). Annals of the Rheumatic Diseases 2019; 78 (6): 802-806. Link: https://ard.bmj.com/content/78/6/802.long Commented by: Luís Inês, MD, PhD. Rheumatologist, CHUC Lupus Clinic, Rheumatology Dpt., … Read more